CRIS

Permanent URI for this communityhttps://investigaciones.utamed.es/handle/123456789/1

Browse

Settings

Access type: UnknownSubject: search.filters.subject.pulse wave velocity

Search Results

Now showing 1 - 1 of 1
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Association between homocysteine levels and arterial stiffness in the adult population: a systematic review and meta-analysis
    (Oxford University Press (OUP), 2026-01-22)
    Saz-Lara, Alicia
    ;
    ;
    Lever-Megina, Carla Geovanna
    ;
    Valladolid-Ayllón, Sara
    ;
    Tébar-García, David
    Purpose The aim was to evaluate the association between homocysteine levels and arterial stiffness in the adult population Methods Scopus, Web of Science, and PubMed databases were searched from their inception to November 30, 2024. The DerSimonian and Laird method was used to calculate pooled odds ratio (OR) estimates and 95% confidence intervals (95% CIs) of the associations between homocysteine levels (plasma and serum homocysteine) and arterial stiffness in the adult population. Results Finally, 17 studies were included in the systematic review, and 16 studies were included in the meta-analysis, and included a total of 31 049 subjects. Our findings provide evidence supporting the associations between plasma homocysteine levels and arterial stiffness (OR: 2.06; 95% CI: 1.50, 2.82) and between serum homocysteine levels and arterial stiffness (OR: 1.76; 95% CI: 1.17, 2.65) in the adult population. Conclusion For each μmol/L unit increase in homocysteine levels, the risk of arterial stiffness increased by 106% for plasma homocysteine and by 76% for serum homocysteine. These findings are of clinical importance for understanding the underlying mechanisms involved in vascular dysfunction to establish preventive strategies in the cardiovascular setting.